Simultaneous Determination of Glycyrrhizin, Glycyrrhetic Acid and Glycyrrhetic Acid Mono-Glucuronide in Shakuyaku-kanzo-to Incubated with Rat Feces by Semi-micro High-Performance Liquid Chromatography.
نویسندگان
چکیده
منابع مشابه
Simultaneous determination of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide in Shakuyaku-kanzo-to incubated with rat feces by semi-micro high-performance liquid chromatography.
A method for semi-micro high-performance liquid chromatography (HPLC) has been established for the simultaneous determination of glycyrrhizin (GL), glycyrrhetic acid (GA) and glycyrrhetic acid mono-glucuronide (GAMG) in incubation mixtures of rat feces with Shakuyaku-kanzo-to decoction (combination of licorice root and peony root). The analysis could be accomplished within 20 min with a TSKgel ...
متن کاملSimultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography.
A method for semi-micro high-performance liquid chromatography (HPLC) has been established for the simultaneous determination of 3alpha-hydroxyglycyrrhetic acid and 3-dehydroglycyrrhetic acid together with glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide formed by incubation of glycyrrhizin with rat feces. The analysis was accomplished within 25 min with a TSKgel ODS-80TsQ...
متن کاملDetermination of Glycyrrhetic Acid in Rat Plasma by HPLC After Oral Administration of Licorice Aqueous Extract
Licorice is obtained from Glycyrrhiza glabra (G. glabra) in Iran. Glycyrrhizin is the main constituent of G. glabra and has several pharmacological effects. It is hydrolyzed to glycyrrhetic acid (GA) in the intestine after oral administration. In this study, a novel HPLC method was used to determine the concentration of GA in rat plasma after oral administration ...
متن کاملGlucuronide-sulfate diconjugate as a novel metabolite of glycyrrhetic acid in rat bile.
To study the metabolites of glycyrrhetic acid (GA) in rat bile, an analytical method was developed to identify GA and its metabolites by liquid chromatography mass spectrometry (LC-MS). Rat bile was collected after i.v. injection of GA. Three major GA-related peaks were detectable in rat bile by high-performance liquid chromatography (HPLC) analysis at 254 nm. LC-MS spectra showed their protona...
متن کاملdetermination of gamma - aminobutyric acid by high-performance liquid chromatography
gamma-aminobutyric acid is the main inhibitory amino acid neurotransmitter in several areas of the brain. measurement of gamma-aminobutyric acid in the brain will help elucidate its metabolic rote and diagnostic value. the liquid chromatography (lc) system consisted of a delivery pump. male rats (150-250g) were used in this study. the brain was rapidly removed from decapitated animals. trie chr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2001
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.24.1161